Reframe Daily: Same-day start to monthly buprenorphine shot; T-cells cut tumor “armor”

Reframe Daily—curated by Christin Chong (neuroscience PhD, Buddhist chaplain, healthtech strategy consultant)—delivers optimistic and credible healthtech updates you won’t find in most popular news outlets, from sources scientists and healthcare providers read and trust.

Today in one sentence: A same-day start protocol for the monthly buprenorphine shot for opioid use disorder worked in a clinical trial, while engineered T-cells cut through a tumor’s collagen “armor” in lab studies; scientists identified nasal “goblet” cells that help viruses latch on—pointing to better sprays or vaccines—and new adult brain cells were shown to help keep memory maps stable.

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Good news: A faster, easier path to long-acting treatment for opioid use disorder can keep more people in care.

Rapid vs Standard Induction to Injectable Extended-Release Buprenorphine

Market readiness: 🙂🙂🙂🙂🙂 (randomized clinical trial using already-approved medication; protocol is implementable in U.S. practice now with clinician oversight). 

Good news: A new T-cell approach breaks through collagen “armor” in solid tumors, helping immune cells get deeper into the tumor.

Collagen-disrupting attIL12 TIL therapy boosts deep T-cell infiltration via dual signaling activation and CCKAR reduction in sarcomas

Market readiness: 🙂🙂 (strong preclinical results in patient-derived models; needs human trials before clinical use). 

Good news: Scientists pinpoint which nasal cells invite viruses in—knowledge that could guide better vaccines or sprays that block infection at the door.

Goblet cells dictate viral tropism and pathogenesis in nasal and intestinal mucosae

Market readiness: 🙂 (mechanistic biology in lab models; informs targets but not a treatment yet). 

Good news: Fresh evidence that boosting new neuron growth can help the brain keep stable, accurate “maps” over time—pointing to future memory-supporting therapies.

Adult-neurogenesis allows for representational stability … (eLife reviewed preprint, Version 1)

Market readiness: 🙂 (fundamental neuroscience; early-stage and preclinical). 

Thank you for taking the time to take care of yourself and your loved ones.